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Saturday, May 31, 2025

The Goldilocks zone for women

by

Dr Vanessa Harry
689 days ago
20230712
Dr Vanessa Harry

Dr Vanessa Harry

A re­cent study has shown that there is a nine-year “just right” Goldilocks zone when it comes to the best age for women to have a ba­by.

This ide­al age range for child­bear­ing is be­tween 23 and 32 years, ac­cord­ing to re­searchers as this group had the low­est risk of birth de­fects.

The study, per­formed at Sem­mel­weis Uni­ver­si­ty in Hun­gary, analysed da­ta from over 31,000 births with con­firmed non-chro­mo­so­mal birth de­fects record­ed in their data­base from 1980 to 2009, and com­pared this with the more than 2.8 mil­lion births reg­is­tered in the coun­try over that same 30-year pe­ri­od.

They found that teenage moms and women in their ear­ly 20s were more like­ly to give birth to chil­dren with de­fects of the cen­tral ner­vous sys­tem, af­fect­ing things like brain and spine de­vel­op­ment, while ma­ture preg­nan­cies were as­so­ci­at­ed most close­ly with de­for­mi­ties of the head, neck, eyes, and ears.

Over­all, the risk of birth de­fects in­creased by about a fifth for births in women un­der the age of 22 com­pared to those with­in the ide­al child­bear­ing win­dow of ages 23 to 32. That risk in­creased by about 15 per cent in women above the age of 32 when com­pared to those with­in the op­ti­mal age win­dow.

In the study, younger moms were 25 per cent more like­ly to see de­fects such as spina bi­fi­da, com­pared to old­er moth­ers. Women who gave birth younger than 20 saw an even greater risk of these prob­lems rel­a­tive to women 23 to 32.

Old­er moth­ers, on the oth­er hand, were twice as like­ly to have a ba­by with mal­for­ma­tions of the eyes, ears, face, and neck caused by an in­fant’s skull or fa­cial bones fus­ing too soon or in an ab­nor­mal way. Women on the old­er end of the spec­trum were al­so more like­ly to see heart de­fects as well as more mal­for­ma­tions of the uri­nary sys­tem than those in the healthy age win­dow.

And old­er moth­ers had a con­sid­er­ably high­er like­li­hood—45 per cent in fact—of giv­ing birth to a ba­by with a cleft lip and palate, while a younger moth­er’s risk in­creased by nine per cent.

Dr Boglár­ka Pethő, as­sis­tant pro­fes­sor at Sem­mel­weis Uni­ver­si­ty and the first au­thor of the study said, “We can on­ly as­sume why non-chro­mo­so­mal birth anom­alies are more like­ly to de­vel­op in cer­tain age groups.

“For young moth­ers, it could be main­ly lifestyle fac­tors (eg, smok­ing, drug or al­co­hol con­sump­tion) and that they are of­ten not pre­pared for preg­nan­cy.

“Among ad­vanced-aged moth­ers, the ac­cu­mu­la­tion of en­vi­ron­men­tal ef­fects such as ex­po­sure to chem­i­cals and air pol­lu­tion, the de­te­ri­o­ra­tion of DNA re­pair mech­a­nisms, and the age­ing of the eggs and en­dometri­um can al­so play a role.”

The re­sult of this study comes as the av­er­age age of moth­ers in many coun­tries con­tin­ues to rise. For in­stance, women in the USA are now giv­ing birth for the first time at ap­prox­i­mate­ly age 30, up from 27 in 2000 and 24 in 1970, and gen­er­al­ly, birth rates are falling world­wide.

A ba­by boom in the mid-20th cen­tu­ry saw the av­er­age woman give birth to be­tween three and four chil­dren. To­day, just 1.6 chil­dren—the low­est lev­el record­ed since da­ta was first tracked in 1800.

Even here at home, it comes as no sur­prise as I con­tin­ue to see women who are opt­ing to de­lay moth­er­hood. This has been at­trib­uted to sev­er­al fac­tors such as chang­ing fam­i­ly val­ues, women pri­ori­tis­ing their ca­reers, and the ris­ing cost of liv­ing, not to men­tion the in­creas­ing con­trol that women can ex­er­cise over their re­pro­duc­tive lives and right­ly so.

How­ev­er, even be­fore this new study was pub­lished, it was al­ready well known that women who get preg­nant and give birth be­yond age 35 typ­i­cal­ly have more dan­ger­ous preg­nan­cies. Old­er moth­ers may be at in­creased risk of mis­car­riage, high blood pres­sure, ges­ta­tion­al di­a­betes, and dif­fi­cult labour.

Pre­vi­ous re­search has al­so con­firmed the as­so­ci­a­tion be­tween old­er ma­ter­nal age and cer­tain ge­net­ic dis­or­ders, name­ly Down’s syn­drome, for which the risk in­creas­es from about one in 1,250 for a woman who con­ceives at age 25, to about one in 100 for a woman who con­ceives at age 40.

Ul­ti­mate­ly, age is just one fac­tor that should go in­to the de­ci­sion to get preg­nant. Emo­tion­al and fi­nan­cial readi­ness is al­so cru­cial, and that tim­ing is unique for each woman. These find­ings of the new study may play a role in guid­ing this de­ci­sion-mak­ing.

columnist


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