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Saturday, June 14, 2025

Mental illnesses and Type 2 diabetes mellitus

by

Caroline Ravello
703 days ago
20230712

Much of what I have learned about liv­ing with and re­cov­er­ing from a men­tal dis­or­der I dis­cov­ered on my own. I re­main grate­ful, how­ev­er, to the physi­cian at the dis­trict health fa­cil­i­ty who spoke with me a decade ago about men­tal ill­ness as a pre­dic­tor of Type 2 di­a­betes mel­li­tus (T2DM).

I dis­cov­ered back then that for a while re­search had been on­go­ing on the link be­tween psy­chi­atric ill­ness­es and the in­ci­dence of di­a­betes, and the cor­re­la­tion of the for­mer with a high­er preva­lence of T2DM.

A di­ag­no­sis of T2DM means that the body is not us­ing in­sulin prop­er­ly and this type is the most com­mon form of di­a­betes.

Re­searchers have long found bidi­rec­tion­al as­so­ci­a­tions where peo­ple liv­ing with de­pres­sion are more like­ly to de­vel­op T2DM, and peo­ple with di­a­betes are more like­ly to de­vel­op de­pres­sion than those who live with­out ei­ther of those con­di­tions.

The present and fu­ture glob­al dan­ger of these as co­mor­bid ill­ness­es, how­ev­er, lies in the high preva­lence of both men­tal ill­ness­es and T2DM as in­di­vid­ual con­di­tions.

The World Health Or­ga­ni­za­tion (WHO, 2021) says that one bil­lion peo­ple (one in eight) glob­al­ly live with a men­tal dis­or­der. The In­ter­na­tion­al Di­a­betes Fed­er­a­tion (IDF, 2022), re­ports that world­wide 537 mil­lion (one in ten) adults aged 20-79 were liv­ing with di­a­betes in 2021, with an ex­pect­ed rise to 643 mil­lion and 783 mil­lion in 2030 and 2045, re­spec­tive­ly.

By them­selves, both psy­chi­atric ill­ness­es and T2DM are re­spon­si­ble for high mor­bid­i­ty and mor­tal­i­ty; both con­tribute to pre­ma­ture deaths. Se­vere men­tal ill­ness­es are known to short­en peo­ple’s life by about 17 years as com­pared to the gen­er­al pop­u­la­tion.

Di­a­betes, the fifth most com­mon cause of death in the world, ac­count­ed for 6.7 mil­lion deaths in 2021 (IDF). And, life ex­pectan­cy, ac­cord­ing to UK re­searchers (2010) is re­duced on av­er­age by up to ten years in peo­ple with T2DM. They es­ti­mat­ed in peo­ple with Type 1 di­a­betes life could be short­ened by more than 20 years.

Re­searchers world­wide al­so agree that my­ocar­dial in­farc­tion (heart at­tack) is the most com­mon cause of death in di­a­bet­ic pa­tients. With­out prop­er in­ter­ven­tion, a di­a­bet­ic pa­tient can de­vel­op phys­i­cal health is­sues such as car­dio­vas­cu­lar dis­ease, cere­brovas­cu­lar dis­ease (strokes), hy­per­ten­sion, neu­ropa­thy (nerve dam­age), and retinopa­thy (eye nerve dam­age) which can lead to blind­ness and oth­er con­di­tions which im­pair health and short­en life ex­pectan­cy. Be­ing di­ag­nosed and man­ag­ing any of these al­so im­pacts a per­son’s men­tal health.

Stud­ies have been done to show that T2DM is more con­se­quen­tial among peo­ple with se­ri­ous men­tal ill­ness­es than in those with­out these con­di­tions, and as well, to show how death in those liv­ing with these con­di­tions as co­mor­bid oc­cur­rences are high­er than when they are not com­bined.

A 2022 Time Mag­a­zine ar­ti­cle ti­tled, The Link Be­tween Type 2 Di­a­betes and Psy­chi­atric Dis­or­ders, quotes Anne Do­her­ty, a Uni­ver­si­ty Col­lege Dublin as­so­ciate pro­fes­sor of psy­chi­a­try say­ing, “When peo­ple who have pre-ex­ist­ing men­tal ill­ness­es de­vel­op di­a­betes, their out­comes are much worse. Com­pared to peo­ple with Type 2 di­a­betes who don’t have men­tal ill­ness­es, they are more like­ly to de­vel­op com­pli­ca­tions, and they’re sig­nif­i­cant­ly more like­ly to die younger.

“The re­la­tion­ship goes both ways; peo­ple with di­a­betes al­so tend to have high­er rates of psy­chi­atric dis­or­ders and face worse out­comes than peo­ple with­out di­a­betes.”

What ex­plains the nexus to some ex­tent is that both men­tal dis­or­ders and di­a­betes have over­lap­ping risk fac­tors, es­pe­cial­ly those of di­et and ex­er­cise.

A per­son liv­ing with a men­tal ill­ness can be faced with symp­toms of fa­tigue, low en­er­gy, so­cial with­draw­al, and a gen­er­al lack of de­sire for phys­i­cal ac­tiv­i­ty. They may not be mo­ti­vat­ed to eat prop­er­ly and may ex­pe­ri­ence weight gain (from oth­er fac­tors re­lat­ed to the men­tal dis­or­der, too). Binge or dis­or­dered eat­ing, which fur­ther ex­ac­er­bate the di­a­bet­ic con­di­tion, may al­so be a fac­tor.

In­ac­tiv­i­ty, poor nu­tri­tion, and weight gain are among the high­est risk fac­tors for de­vel­op­ing T2DM.

Seena Fazel, an Ox­ford Uni­ver­si­ty foren­sic psy­chi­a­try pro­fes­sor who was al­so quot­ed in Time Mag­a­zine says, “De­pres­sion can make it hard­er to ex­er­cise, eat healthy, or ad­here to a med­ica­tion reg­i­men, all of which can in­crease di­a­betes risk.”

Fazel said a per­son with a men­tal dis­or­der of­ten may “self-med­icate with al­co­hol and drugs”, and that sleep dis­rup­tion, which is com­mon with psy­chi­atric ill­ness­es, presents as a risk fac­tor.

When di­ag­nosed with T2DM, an in­di­vid­ual may be emo­tion­al­ly af­fect­ed and may strug­gle with is­sues of de­nial, fear, anger, ir­ri­ta­tion and oth­er emo­tions that can prompt de­pres­sion, anx­i­ety, and stress.

Added to the dilem­ma is the fact that of­ten pa­tients with chron­ic health con­di­tions such as T2DM do not re­ceive care, in­ter­ven­tions or coun­selling about their men­tal health. Very of­ten clin­i­cal in­ter­ven­tions may ig­nore the fact that an in­te­grat­ed ap­proach to treat­ment of mul­ti­ple ill­ness­es is nec­es­sary to pro­mote pa­tients’ over­all well-be­ing.

Risk fac­tors

What ex­plains the nexus to some ex­tent is that both men­tal dis­or­ders and di­a­betes have over­lap­ping risk fac­tors, es­pe­cial­ly those of di­et and ex­er­cise.

A per­son liv­ing with a men­tal ill­ness can be faced with symp­toms of fa­tigue, low en­er­gy, so­cial with­draw­al, and a gen­er­al lack of de­sire for phys­i­cal ac­tiv­i­ty. They may not be mo­ti­vat­ed to eat prop­er­ly and may ex­pe­ri­ence weight gain (from oth­er fac­tors re­lat­ed to the men­tal dis­or­der, too). Binge or dis­or­dered eat­ing, which fur­ther ex­ac­er­bate the di­a­bet­ic con­di­tion, may al­so be a fac­tor.

In­ac­tiv­i­ty, poor nu­tri­tion, and weight gain are among the high­est risk fac­tors for de­vel­op­ing T2DM.

Seena Fazel, an Ox­ford Uni­ver­si­ty foren­sic psy­chi­a­try pro­fes­sor who was al­so quot­ed in Time Mag­a­zine says, “De­pres­sion can make it hard­er to ex­er­cise, eat healthy, or ad­here to a med­ica­tion reg­i­men, all of which can in­crease di­a­betes risk.”

Fazel said a per­son with a men­tal dis­or­der of­ten may “self-med­icate with al­co­hol and drugs”, and that sleep dis­rup­tion, which is com­mon with psy­chi­atric ill­ness­es, presents as a risk fac­tor.

When di­ag­nosed with T2DM, an in­di­vid­ual may be emo­tion­al­ly af­fect­ed and may strug­gle with is­sues of de­nial, fear, anger, ir­ri­ta­tion and oth­er emo­tions that can prompt de­pres­sion, anx­i­ety, and stress.

Added to the dilem­ma is the fact that of­ten pa­tients with chron­ic health con­di­tions such as T2DM do not re­ceive care, in­ter­ven­tions or coun­selling about their men­tal health. Very of­ten clin­i­cal in­ter­ven­tions may ig­nore the fact that an in­te­grat­ed ap­proach to treat­ment of mul­ti­ple ill­ness­es is nec­es­sary to pro­mote pa­tients’ over­all well-be­ing.

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